Cause	Bacteria - Calymmatobacterium granulomatis.
Distribution	Countries with warm humid climates for example, Africa, Papua New Guinea, Southern India and South USA.
Transmission	Sexual
Incubation	Uncertain, probably long.
Symptoms	Red painless nodule which develops into a raised ulcer with a raw beefy surface.
Diagnosis	Physical examination. Microscopic examination of crushed tissue. Skin biopsy.
Treatment	Tetracycline and co-trimoxazole (a sulphonamide containing antibiotic) by mouth or streptomycin injections.
Complications	Severe scarring causing obstruction to the flow of lymph (a tissue fluid). This may lead to genital elephantiasis (swelling and distortion of the genitals). Untreated infection may spread to the surrounding skin and to the rectum. Cancerous change may develop in long-standing untreated cases.